Codon usage bias and environmental adaptation in microbial organisms
نویسندگان
چکیده
منابع مشابه
More Codon Usage Bias
χ measure. In statistics, the χ statstic computes how different the distribution of values is from a uniform distribution. Let d = c1 . . . cN be a DNA string in nucleotide alphabet, and let L be the total number of codons in d that are not Methinine or Tryptophan (the number does include the stop codons though). Let a be a k-degenerate amino acid, and let La be the total number of codons codin...
متن کاملEnvironmental shaping of codon usage and functional adaptation across microbial communities
Microbial communities represent the largest portion of the Earth's biomass. Metagenomics projects use high-throughput sequencing to survey these communities and shed light on genetic capabilities that enable microbes to inhabit every corner of the biosphere. Metagenome studies are generally based on (i) classifying and ranking functions of identified genes; and (ii) estimating the phyletic dist...
متن کاملThe codon Adaptation Index--a measure of directional synonymous codon usage bias, and its potential applications.
A simple, effective measure of synonymous codon usage bias, the Codon Adaptation Index, is detailed. The index uses a reference set of highly expressed genes from a species to assess the relative merits of each codon, and a score for a gene is calculated from the frequency of use of all codons in that gene. The index assesses the extent to which selection has been effective in moulding the patt...
متن کاملRelative Codon Adaptation Index, a Sensitive Measure of Codon Usage Bias
We propose a simple, sensitive measure of synonymous codon usage bias, the Relative Codon Adaptation Index (rCAI), as a way to discriminate better between highly biased and unbiased regions, compared with the widely used Codon Adaptation Index (CAI). CAI is a geometric mean of the relative usage of codons in a gene, and is calculated using the codon usage table trained with a set of highly expr...
متن کاملAn Investigation of Codon Usage Bias Including Visualization and Quantification in Organisms Exhibiting Multiple Biases
Prokaryotic genomic sequence data provides a rich resource for bioinformatic analytic algorithms. Information can be extracted in many ways from the sequence data. One often overlooked process involves investigating an organism’s codon usage. Degeneracy in the genetic code leads to multiple codons coding for the same amino acids. Organism’s often preferentially utilize specific codons when codi...
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ژورنال
عنوان ژورنال: Molecular Genetics and Genomics
سال: 2021
ISSN: 1617-4615,1617-4623
DOI: 10.1007/s00438-021-01771-4